Gastric cancer management: Kinases as a target therapy
نویسندگان
چکیده
منابع مشابه
Target Therapy in Gastric Cancer
Gastric cancer is the fifth most frequently diagnosed cancer and the third leading cause of cancer mortality. In advanced gastric cancer patients, the treatment outcomes are dismal. With the development of the molecular targeted therapy, the prognosis in patients with advanced and unresectable gastric cancer are improved. This article reviewed the molecular targeted agents in clinical use, thei...
متن کاملAurora kinases as an anti-cancer target.
The Aurora family of serine/threonine kinases plays an important role in chromosome alignment, segregation and cytokinesis during mitosis. Recent studies have found aberrant expression of Aurora kinases in a variety of human solid tumors and hematological malignancies, suggesting they have a role in carcinogenesis. This review highlights the function of Aurora kinases in the regulation of mitos...
متن کاملTyrosine kinases as targets for cancer therapy.
Enhanced protein tyrosine kinase (PTK) activity correlates with the development of cancer and other proliferative diseases. The hypothesis that PTK inhibitors may be of value in the treatment of cancer led to the systematic synthesis of selective tyrosine phosphorylation inhibitors (tyrphostins) that show in vitro and in vivo anticancer activity. This review will provide an overview of research...
متن کاملPolymorphisms of Antioxidant’ Genes as a Target for Diabetes Management
Diabetes mellitus (DM) is one of the most important health problems with increasing prevalence worldwide. Oxidative stress that is a result of imbalance between reactive oxygen species (ROS) generation and antioxidant defense mechanisms has been demonstrated as a main pathology in DM. Hyperglycemia-induced ROS productions can induce oxidative stress through four major molecular mechanisms inclu...
متن کاملP14: Mitochondria as a Target for Drug Therapy in Epilepsy
لطفاً به چکیده انگلیسی مراجعه شود.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Clinical and Experimental Pharmacology and Physiology
سال: 2017
ISSN: 0305-1870
DOI: 10.1111/1440-1681.12743